Polysorbate 80: Dangerous and Toxic

 In News


By Dr. Palevsky

Polysorbate 80 is used as an emulsifier by the pharmaceutical industry to enhance the delivery of chemicals/drugs from the blood into the brain across the blood brain barrier (BBB). Being that the BBB is impermeable to many things in the bloodstream, researchers needed to find a way to deliver chemicals/drugs into the brain from the bloodstream in order to treat hard-to-reach brain infections/lesions/tumors, etc. Polysorbate 80 is one such chemical that helps in this delivery. (study here). 

Since vaccines contain polysorbate 80, we can ask the following questions;

  • What vaccine materials get across the BBB, with the help of polysorbate 80, into the brain of children? and
  • What effect do they have once they get into the brain? Do they contribute to inflammation, toxicity, encephalitis?

Since polysorbate 80 works as an emulsifier, and will also enhance the delivery of vaccine materials into the rest of the cells of the body,

  • What vaccine materials enter the cells of our bodies?
  • Do they remain in the cells once they get in there?
  • Do they impair any parts of the cells, i.e, mitochondrial DNA, nuclear DNA, or other cellular apparatuses – endoplasmic reticulum, golgi apparatus?
  • Do they become part of the DNA of the cells since there are whole DNA strands from live viruses in the vaccines, along with foreign animal DNA and bacterial/viral/yeast protein antigens?
  • If they do become part of the DNA, how does this change the function and/or regulatory systems in the cells?
  • Do the materials from vaccines (e.g. aluminum, mercury, formaldehyde) entering through the cell membranes at the hands of polysorbate 80 do anything to impair the electrical charge of the cell membrane, or impair/alter the way materials enter or exit the cell through the cell membrane (nutrients, cellular wastes, manufactured proteins, or enzymes?

Since babies have a poorly developed BBB, which may not solidify for at least the first 6 months, or maybe longer if they have a brewing inflammatory condition yet to be determined that has delayed the full development of the BBB, then questions 3-8 apply to their brains as well.

We don’t know the answers to most/all of these questions because studies have never been done to evaluate them.
We use vaccines all for the sake of producing an antibody to bacteria and viruses that might not give us protection against getting the diseases anyway.
Of note, we are already protected against getting diseases from trillions of bacteria and viruses that live along the linings of our bodies and within the DNA of our cells, for which we don’t have antibodies, so antibodies are not the be-all and end-all of protection from disease. Even the textbooks, the literature, and the CDC admit to this.

With ever-increasing cases of significant neuro-inflammatory conditions in this country, and the fact that the US has one of the highest rates of chronic inflammatory conditions in the world, shouldn’t we know the answers to these questions?

Studies on Polysorbate 80

Polysorbate 80 allows toxins into the brain

Polysorbate 80 also opens up the blood-brain barrier allowing toxins into the brain, which would otherwise not reach the brain.
These studies show the use of Polysorbate 80 in drug development as a means to cross the blood-brain barrier, which is there to protect us from these toxins crossing the barrier.

The Blood-Brain Barrier: Bottleneck in Brain Drug Development. NeuroRx, 2005

Preparation and Therapeutic Efficacy of Polysorbate-80-Coated Amphotericin B/PLA-b-PEG Nanoparticles. Journal of Biomaterials Science 20 (2009)

Tween 80 containing lipid nanoemulsions for delivery of indinavir to brain. Acta Pharmaceutica Sinica B, 2013

Stealth lipid polymer hybrid nanoparticles loaded with rutin for effective brain delivery – comparative study with the gold standard (Tween 80): optimization, characterization and biodistribution. Drug Delivery, 2017

Superparamagnetic Iron Oxide Nanoparticles Modified with Tween 80 Pass through the Intact Blood-Brain Barrier in Rats under Magnetic Field. ACS Applied Materials and Interfaces, 2016

Polysorbate 80 and Infertility

Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions. Annals of Allergy, Asthma and Immunology, 2005

The study included a pregnant woman who suffered anaphylactic shock after being given a IV drip of multi-vitamins containing polysorbate 80.

It is of current relevance as a ‘hidden’ inductor of anaphylactoid reactions”, and “Polysorbate 80 was identified as the causative agent for the anaphylactoid reaction of nonimmunologic origin in the patient. Conclusions: Polysorbate 80 is a ubiquitously used solubilizing agent that can cause severe nonimmunologic anaphylactoid reactions.

Delayed effects of neonatal exposure to Tween 80 on female reproductive organs in rats. Food and Chemical Toxicology, 1993

Baby female rats were injected with polysorbate 80 at days 4-7 after birth. It accelerated the maturing of the rats and caused changes to the vagina and womb lining, hormonal changes, ovary deformities and degenerative follicles.

Treatment with Tween 80 accelerated maturation, prolonged the oestrus cycle, and induced persistent vaginal oestrus. The relative weight of the uterus and ovaries was decreased relative to the untreated controls. Squamous cell metaplasia of the epithelial lining of the uterus and cytological changes in the uterus were indicative of chronic oestrogenic stimulation. Ovaries were without corpora lutea, and had degenerative follicles.


Polysorbate 80 is a chemical used by physicians to open the blood-brain barrier, for the purpose of chemotherapy for brain cancer. The chemicals then bind tightly to the polysorbate 80 and the chemo can reach the cancer cells.

Polysorbate 80 is used in vaccines to reduce the surface tension of the chemicals, and increase the solubility of chemicals that normally would not be able to dissolve together (think oil and water). It also works as an emulsifier so the chemicals can disperse evenly upon injection.

This sounds like a smart plan, right? The problem is, it also opens the blood-brain barrier and the brain is exposed to the chemicals like aluminum (a neurotoxin), formaldehyde (embalming fluid and a carcinogen), glyphosate (another carcinogen), etc. Since it increases solubility and absorbability, it makes it incredibly easy for the brain to absorb the toxins; the toxins bind tightly to the polysorbate 80 and flow right through the blood-brain barrier to do their damage.

Not only does polysorbate 80 open up the brain to toxins, it can potentially be toxic itself. There are numerous studies linking it to infertility, anaphylactic shock, cardiac issues, cancer and even death. See the studies below.

Many of the studies on the toxicity of polysorbate 80 (also called Tween 80) only test via inhalation or ingestion versus injection. But when something is ingested, it is only 1-3% absorbed into the body because the toxin goes through our bodies natural detox filter pathway. But injected toxins go straight into the bloodstream and bypass this pathway — meaning 95+% is absorbed into body tissues. Eventually these toxins will accumulate and cause a health issue. Injection is very different from ingestion.

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Showing 3 comments
  • ZYX 10

    I really like it when individuals come together and share opinions.
    Great site, continue the good work! https://zyx10.org/

  • Lynn Tarrence

    I have had a serious allergic reaction after taking a loading dose of Cosentyx which contains Polysorbate 80. I was a
    Identified by the U of Cal SanDiego immunology and allergy department. I have Rheumatoid Arthritis and had similar reactions to Remicade, Humira, and now the cosentyx. I have had continued reactions since my last dose two weeks ago. Facial swelling, lip and eyelid swelling and breathing issues. How long will it take for this poison to leave my system

    • Brandy Vaughan

      Hi Lynn,
      I’m so sorry about the reactions. Clearly, those drugs are not working well with your body. I would suggest finding a good “health” care tema that can help you detox and recover your health while minimizing the pain of RA. We have good detox ideas here: http://www.LearnTheRisk.org/detox and a good list of real health practitioners here: http://www.LearnTheRisk.org/partners
      If you’re in the San Diego area, you can email us for other possible options locally. [email protected]

      Best of luck on your journey back to health!

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