Application of the immunological disease continuum to study autoimmune and other inflammatory events after vaccination.

Emerging data suggest that self-directed tissue inflammation occurs along a continuum from innate immune-driven diseases to adaptive immune-driven diseases.” Vaccine 2011

Can influenza H1N1 vaccination lead to the membranous glomerulonephritis?

“So this case report is about a 56-year-old man, who developed membranous glomerulonephritis 23 days after the vaccination against Influenza A (H1N1) virus.”
Indian Journal of Pathology and Microbiology 2012

A case of Evans’ syndrome following influenza vaccine.

“CASE REPORT: A 50-year-old man with no prior medical history developed Evans’ syndrome 4 days after receiving influenza immunization. The patient improved following treatment with oral prednisone and intravenous immunoglobulin.” Emergency Medicine 2013

The common immunogenic etiology of chronic fatigue syndrome: from infections to vaccines via adjuvants to the ASIA syndrome.

Recently, the AISA (autoimmune/inflammatory syndrome induced by adjuvants) syndrome was recognized, indicating the possible contribution of adjuvants and vaccines to the development of autoimmunity.
Infectious Disease Clinics of North America 2011

A comprehensive review of mercury provoked autism

“Emerging evidence supports the theory that some autism spectrum disorders (ASDs) may result from a combination of genetic/biochemical susceptibility, specifically a reduced ability to excrete mercury (Hg), and exposure to Hg at critical developmental periods.”

Demyelinating disease and vaccination of the human papillomavirus

“CONCLUSIONS: Have been described seizures, autoimmune disorders such as Guillain-Barre syndrome, transverse myelitis, or motor neuron disease, probably adverse effects following immunization by HPV vaccine. So we suggest that vaccine may trigger an immunological mechanism leading to demyelinating events, perhaps in predisposed young.”  Revue Neurologique 2011

Erythema multiforme following vaccination for human papillomavirus.

“In our patient, the temporal relationship between the development of EM {Erythema multiforme} and the vaccination suggests that the HPV vaccine probably was the causal agent.” Dermatology 2010

Gastrointestinal immunopathology and food allergy.

“In contrast to the beneficial expressions of gastrointestinal-associated lymphoid tissue, which are seen with relevance to newer methods of delivery of vaccines directly applied to the gastrointestinal mucosal surfaces (eg, oral poliovirus, rotavirus, Salmonella typhi vaccines), the adverse consequences of a mucosal immune response gone astray are evidenced in many diseases such as FA. A classification of clinical disorders associated with FA based on classic mechanisms of immunologic injury is presented, which includes the following: (1) IgE-mediated, (2) non-IgE-mediated, and (3) mixed IgE- and non-IgE-mediated disorders. Our study of immunologic disturbance in patients with non-IgE FA revealed a pattern of increased CD4+ and decreased TH1 cell counts in peripheral blood mononuclear cells in contrast to patients with celiac disease, where a pattern of increased CD8+ and TH1 cell counts in peripheral blood mononuclear cells and increased CD8+ cell counts was seen.”

Infection, vaccination, and autoantibodies in chronic fatigue syndrome, cause or coincidence?

“RESULTS: In contrast to the beneficial expressions of gastrointestinal-associated lymphoid tissue, which are seen with relevance to newer methods of delivery of vaccines directly applied to the gastrointestinal mucosal surfaces (eg, oral poliovirus, rotavirus, Salmonella typhi vaccines), the adverse consequences of a mucosal immune response gone astray are evidenced in many diseases such as FA {food allergy}.” Annals of Allergy, Asthma & Immunology 2004

Measles inclusion-body encephalitis caused by the vaccine strain of measles virus.

“We report a case of measles inclusion-body encephalitis (MIBE) occurring in an apparently healthy 21-month-old boy 8.5 months after measles-mumps-rubella vaccination.” Clinical Infectious Diseases 1999

Mumps vaccine associated orchitis: Evidence supporting a potential immune-mediated mechanism.

“We report 3 cases of orchitis following vaccination with mumps-measles-rubella (MMR) vaccine, two with an onset within 3 days following vaccination. Orchitis is a common complication of mumps infection, particularly in post-pubertal males, and is also recognized as a very rare complication of mumps vaccination. These cases, discussed together with a comprehensive review of the existing literature regarding post-vaccine orchitis, highlight uncertainty regarding the pathogenesis of post-vaccine orchitis.” Vaccine 2010

A possible central mechanism in autism spectrum disorders, part 1.

This mechanism explains the link between excessive vaccination, use of aluminum and ethylmercury as vaccine adjuvants, food allergies, gut dysbiosis, and abnormal formation of the developing brain.Alternative Therapies In Health And Medicine 2008

Possible Triggering Effect of Influenza Vaccination on Psoriasis.

“The aim of this study is to investigate the effects of influenza vaccination on patients with psoriasis.” Journal of Immunology Research 2015

The Putative Role of Environmental Mercury in the Pathogenesis and Pathophysiology of Autism Spectrum Disorders and Subtypes. (2017)

“Environmental mercury is neurotoxic at doses well below the current reference levels considered to be safe, with evidence of neurotoxicity in children exposed to environmental sources including fish consumption and ethylmercury-containing vaccines.” Molecular Neurobiology 2018

Smallpox and smallpox vaccination: neurological implications.

“Cutaneous complications of vaccination occur in immunosuppressed subjects and in those with atopic dermatitis.” Neurology. 2003

Subacute thyroiditis and dyserythropoesis after influenza vaccination suggesting immune dysregulation.

“We describe a case of subacute thyroiditis and dyserythropoesis occurring shortly after administration of an influenza vaccine in a 55-year-old man with history of diabetes and psoriasis, family history of autoimmunity without clinical evidence of acute viral infection prior to the onset of symptoms.” Boletin De La Asociacion Medica De Puerto Rico 2011

Surveillance of adverse events after the first trivalent inactivated influenza vaccine produced in mammalian cell culture (Flucelvax(®)) reported to the Vaccine Adverse Event Reporting System (VAERS), United States, 2013-2015.

“Among 309 reports with an AE documented, 19 (6.1%) were serious and the most common categories were 152 (49.2%) general disorders and administration site conditions (mostly injection site and systemic reactions) and 73 (23.6%) immune system disorders with two reports of anaphylaxis. Four reports of GBS were submitted. Disproportional reporting was identified for ‘drug administered to patient of inappropriate age.’” Vaccine 2015

Systemic Immune Response to Vaccination on FDG-PET/CT.

“A patient with newly diagnosed right lung cancer had transient 18F-fluorodeoxyglucose (FDG)-avid left axillary lymph nodes and intense splenic FDG uptake on positron emission tomography (PET)/computed tomography (CT). History revealed that the patient received a left-sided influenza vaccine 2-3 days before the examination.” Nuclear Medicine and Molecular Imaging 2016

Transverse myelitis and vaccines: a multi-analysis.

“We have disclosed 37 reported cases of transverse myelitis associated with different vaccines including those against hepatitis B virus, measles-mumps-rubella, diphtheria-tetanus-pertussis and others, given to infants, children and adults.” Lupus 2009

Vaccinations and secondary immune thrombocytopenia with antiphospholipid antibodies by human papillomavirus vaccine.

“A 13-year-old girl developed immune thrombocytopenic purpura (ITP) and concomitant positive antiphospholipid antibodies (aPL) following vaccination with a quadrivalent human papillomavirus (HPV) vaccine. During the course of a disease, she developed clinical manifestation with bleeding and she was treated with intravenous immunoglobulins. Consequently, the number of her platelets remained critically low and she was put on corticosteroids and rituximab. Since then, her platelet count remain within the normal range, but her aPL are still present.” Seminars in Hematology 2016

Vaccine-associated immune-mediated hemolytic anemia in the dog

“This study provides the first clinical evidence for a temporal relationship of vaccine-associated IMHA in the dog.Journal of Veterinary Internal Medicine 1996