Association between type 1 diabetes and Hib vaccine.

Study on the effect of the Haemophilus influenzae type b vaccine on type 1 diabetes and found that the data supports a causal relation. Furthermore, the potential risk of the vaccine exceeds the potential benefit. British Medical Journal, 1999

A causal association between Haemophilus influenzae type b (Hib) vaccine and diabetes. Autoimmunity, 2003

Adverse events associated with childhood vaccines other than pertussis and rubella. Summary of a report from the Institute of Medicine.

In September 1993, the Institute of Medicine released a report entitled Adverse Events Associated With Childhood Vaccines: Evidence Bearing on Causality. The report examined putative serious adverse consequences associated with administration of diphtheria and tetanus toxoids; measles, mumps, and measles-mumps-rubella vaccines; oral polio vaccine and inactivated polio vaccine; hepatitis B vaccines; and Haemophilus influenzae type b (Hib) vaccines.” JAMA 1994

Adverse events following Haemophilus influenzae type b vaccines in the Vaccine Adverse Event Reporting System, 1990-2013.

“Includes 29 747 reports after Hib vaccines; 5179 (17%) were serious, including 896 reports of deaths. Median age was 6 months (range 0-1022 months). Sudden infant death syndrome was the stated cause of death in 384 (51%) of 749 death reports with autopsy/death certificate records.” Journal of Pediatrics 2015

Adverse events following vaccination in premature infants.

The aims of this study were to study the frequency, severity and types of adverse reactions following DPT/Hib (diphtheria and tetanus toxoids and pertussis/Haemophilus influenzae type B conjugate) immunization in very preterm infants and to identify possible risk factors.” Acta Paediatrica 2001

Apnea after immunization of preterm infants.

“However, 12 (12%) infants experienced a recurrence of apnea, and 11 (11%) had at least a 50% increase in the number of apneic and bradycardic episodes in the 72 hours after immunization.” Journal of Pediatrics 1997

Clustering of cases of insulin dependent diabetes (IDDM) occurring three years after hemophilus influenza B (HiB) immunization support causal relationship between immunization and IDDM.

“OBJECTIVE: The hemophilus vaccine has been linked to the development of autoimmune type 1 diabetes, insulin dependent diabetes (IDDM) in ecological studies.” Autoimmunity 2002

An evaluation of the effects of thimerosal on neurodevelopmental disorders reported following DTP and Hib vaccines in comparison to DTPH vaccine in the United States.

“Significantly increased odds ratios for autism, speech disorders, mental retardation, infantile spasms, and thinking abnormalities reported to VAERS were found following DTP vaccines in comparison to DTPH vaccines with minimal bias or systematic error.” Journal of Toxicology and Environmental Health 2006

Guillain-Barré syndrome following immunisation with Haemophilus influenzae type b conjugate vaccine

“The Guillain-Barré syndrome (GBS) is an immune-mediated disease often associated with viral or bacterial infections and with immunisation. IgM antibodies have been implicated as the main trigger event in GBS. So far, only four cases of GBS have been observed following immunisation with a conjugate vaccine against Haemophilus influenzae type b.” European Journal of Pediatrics 1993

Haemophilus influenzae type b meningitis in a vaccinated and immunocompetent child

“Invasive Haemophilus influenzae type b (Hib) disease decreased dramatically after the introduction of conjugate vaccine in routine immunization schedules. We report a case of a fifteen-months-old girl, previously healthy and vaccinated, admitted in the emergency room with fever and vomiting.” Journal of Infection and Public Health 2017

Haemophilus influenzae Type b Meningitis in the Short Period after Vaccination: A Reminder of the Phenomenon of Apparent Vaccine Failure.

“We present two cases of bacterial meningitis caused by Haemophilus influenzae type b (Hib) which developed a few days after conjugate Hib vaccination. This phenomenon of postimmunization provocative time period is reviewed and discussed. These cases serve as a reminder to clinicians of the risk, albeit rare, of invasive Hib disease in the short period after successful immunization.” Case Reports in Infectious Diseases 2012

Hypothesis: conjugate vaccines may predispose children to autism spectrum disorders

“This period of hypo-responsiveness to carbohydrate antigens coincides with the intense myelination process in infants and young children, and conjugate vaccines may have disrupted evolutionary forces that favored early brain development over the need to protect infants and young children from capsular bacteria.” Medical Hypotheses 2011

Hypotonic-hyporesponsive episode in a 7-month-old infant after receipt of multiple vaccinations.

“A 7-month-old boy became difficult to arouse, was limp and had blue extremities 8 hours after immunization with intravenous poliovirus, diphtheria-tetanus toxoids-acellular pertussis, Haemophilus influenzae type b-hepatitis B virus and pneumococcal vaccines. The hypotonic-hyporesponsive episode had resolved by the time the infant was seen in an emergency department 1 hour later. The report describes hypotonic-hyporesponsive episode, encourages reporting of vaccine-associated adverse events and discusses prognosis and implications for subsequent immunization.” The Pediatric Infectious Disease Journal 2005

Hypotonic-hyporesponsive episodes reported to the Vaccine Adverse Event Reporting System (VAERS), 1996-1998

“BACKGROUND: A hypotonic-hyporesponsive episode (HHE) is the sudden onset of hypotonia, hyporesponsiveness, and pallor or cyanosis that occurs within 48 hours after childhood immunizations. This syndrome has been primarily associated with pertussis-containing vaccines administered to children <2 years of age, and has been estimated to occur once every 1750 diphtheria-tetanus-pertussis (DTwP) vaccinations. Previous studies of HHE were limited by small numbers of cases and, sometimes, by limited details of the event. Pediatrics 2000

Origins of and solutions for neonatal medication-dispensing errors.

“The medication mix-ups involved adult and neonatal phytonadione injectable emulsion, sodium citrate injection and vancomycin-heparin combination injection, adult tetanus-diphtheria-acellular pertussis and infant diphtheria-tetanus-acellular pertussis (DTaP) vaccines, Haemophilus B and DTaP vaccines, and cisatracurium and vecuronium.” American Journal of Health-System Pharmacy 2010

Public should be told that vaccines may have long term adverse effects

“Jefferson’s editorial about vaccination and its adverse effects mentions our research.1 We found that immunisation starting at birth was associated with a decreased risk of insulin dependent diabetes, while immunisation starting after age 2 months was associated with an increased risk of diabetes in both rodents and humans.” BMJ 1999

Severe apnoeas following immunisation in premature infants.

“Four premature infants developed apnoeas severe enough to warrant resuscitation after immunisation with diphtheria, pertussis, and tetanus (DPT), and Haemophilus influenzae B (Hib). One required re-intubation and ventilation. Although apnoeas after immunisation are recognised, they are not well documented. It is time for further research to elucidate the best time to immunise such infants.” Archives of disease in childhood. Fetal and neonatal 1999

Vaccination failure: case report of Haemophilus influenzae b meningitis in a 14-month-old child

“We described the case of a 14-months-old child showing a bacterial purulent meningitis with Hib, despite of a well driven vaccination.” Pathologie Biologie 2005