Anaphylactic reactions to measles-mumps-rubella vaccine in three children with allergies to hen’s egg and cow’s milk.

“AIM: Allergies to hen’s egg and cow’s milk are the most frequent food allergies in infancy and childhood. Current guidelines recommend safe administration of measles-mumps-rubella (MMR) vaccine in egg allergic patients.”

Anaphylaxis after zoster vaccine: Implicating alpha-gal allergy as a possible mechanism.

“Gelatin and other nonprimate mammal–derived products are common excipient ingredients in several vaccines, and it has been postulated that patients with alpha-gal allergy might react to these vaccines.”

A clinical analysis of gelatin allergy and determination of its causal relationship to the previous administration of gelatin-containing acellular pertussis vaccine combined with diphtheria and tetanus toxoids.

“Most anaphylactic reactions and some urticarial reactions to gelatin-containing measles, mumps, and rubella monovalent vaccines are associated with IgE-mediated gelatin allergy. DTaP immunization histories suggest that the gelatin-containing DT”

Effects of diphtheria-tetanus-pertussis or tetanus vaccination on allergies and allergy-related respiratory symptoms among children and adolescents in the United States.

“The odds of having a history of asthma was twice as great among vaccinated subjects than among unvaccinated subjects”
“DTP or tetanus vaccination appears to increase the risk of allergies and related respiratory symptoms in children and adolescents.”

Food allergy to gelatin in children with systemic immediate-type reactions, including anaphylaxis, to vaccines. 

We reconfirmed a strong relationship between systemic immediate-type allergic reactions, including anaphylaxis, to vaccines and the presence of specific IgE to gelatin. Moreover, some of the children also had allergic reactions to food gelatin before or after vaccination.”

Gastrointestinal immunopathology and food allergy. 

The gastrointestinal immune response thus plays a pivotal role in maintaining protective immunity in health and a critical role in the pathogenesis of a wide variety of clinical disorders associated with FA.

Infection of human B lymphocytes with MMR vaccine induces IgE class switching.

Here, we show that infection of a human IgM(+) B cell line with MMR resulted in the expression of germline epsilon transcript. In addition, infection of freshly prepared human PBLs with this vaccine resulted in the expression of mature IgE mRNA transcript. Our data suggest that a potential side effect of vaccination with live attenuated viruses may be an increase in the expression of IgE.”

Is infant immunization a risk factor for childhood asthma or allergy?

The authors shows a correlation between the diphtheria/pertussis/tetanus (DPT) and polio immunizations and asthma episodes, asthma consultations, and consultations for other allergic illness. These findings do not appear to be due to differential use of health services (although this possibility cannot be excluded) or confounding by ethnicity, socioeconomic status, parental atopy, or parental smoking.

Pertussis adjuvant prolongs intestinal hypersensitivity.

“Our findings indicate nanogram quantities of PT [pertussis toxin], when administered with a food protein, result in long-term sensitization to the antigen, and altered intestinal neuroimmune function. These data suggest that exposure to bacterial pathogens may prolong the normally transient immune responsiveness to inert food antigens.”

A possible central mechanism in autism spectrum disorders and gut disorders

“A careful review of ASD cases discloses a number of events that adhere to an immunoexcitotoxic mechanism. This mechanism explains the link between excessive vaccination, use of aluminum and ethylmercury as vaccine adjuvants, food allergies, gut dysbiosis, and abnormal formation of the developing brain.”

Potential risk of repeated nasal vaccination that induces allergic reaction with mucosal IgE and airway eosinophilic infiltration in cynomolgus macaques infected with H5N1 highly pathogenic avian influenza virus. 

“On the other hand, eosinophil clusters were observed in the lungs of vaccinated macaques. Although Vac-3-specific IgE antibody and IL-13 levels were decreased after infection compared to those before infection and no anaphylaxis in vaccinated macaques was detected after challenge infection, our results suggest that we have to pay attention to potential allergic responses at repeated nasal vaccination, especially in people who have an airway allergy.”

Rabies post-exposure prophylaxis for a child with severe allergic reaction to rabies vaccine.  

Most adverse events (AEs) during the immunization of rabies vaccine were slight, there was little information about the allergic reaction induced by rabies vaccines and had to stop or change the immunization program. Here, we reported a case that a 4-year-old boy had category II exposure to rabies and showed severe allergic reaction after being immunized with lyophilized purified vero cell rabies vaccine (PVRV).

Semple rabies vaccine: presence of myelin-basic protein and proteolipid protein and its activity in experimental allergic encephalomyelitis. 

These results suggest that MBP in vaccines may play a decisive role in the production of PVE.

Timing of routine infant vaccinations and risk of food allergy and eczema at one year of age. 

“Delayed DTaP was associated with reduced eczema and reduced use of eczema medication. Timing of routine infant immunizations may affect susceptibility to allergic disease.”